Sudan Medical Laboratory Journal

Omdurman Islamic University

The Mannich Reaction is used in the synthesis of natural products and pharmaceuticals. Therefore in this review we discuss the medicinal uses of Mannich bases with examples in the medicinal field. A large number of different bioactivities of  Mannich bases are  anticonvulsant, antimalarial, anticancer, analgesic and antimicrobial drugs. Also Mannich bases are used as prodrugs.